The aim of SymSIm team is to understand the cellular and molecular processes involved in bacteriocyte cell differentiation and to unravel the mechanisms of endosymbiont control and their maintenance throughout host generations. These functional investigations use genomic and integrative approaches in order to decipher the molecular dialogue occurring between bacteria and insects. The team aims to understand how symbiosis is integrated into the insect organization, at the level of the organism (metabolism, physiology), cells (differentiation and organization of bacteriocytes), and molecules (signaling pathways involved, regulation). SymSIm team also intends to unravel how the insect immune system would have evolved to both tolerate and control the presence of bacteria within the host system.
A second field of interest to SymSIm team is to understand the evolutionary bases of intracellular symbiosis within the coleopteran super family Curculionoidea. This work that uses phylogenetic and histological techniques aims at analysing the diversity of intracellular symbiosis within this large super family and to learn about symbiosis impact on insect adaptation and evolution.